A biotechnology company working on the reversal of human ageing.
Chronos Biosciences is at an early stage. The work under way is to review the published evidence across the active fronts of the field, document the scope and limitations of each one, and establish evaluation criteria before starting experimental work of our own.
Focus
The field currently works across several fronts with solid preclinical evidence and uneven clinical progress. Chronos Biosciences follows four of them, plus a fifth, cross-cutting problem that constrains all the others.
Senescent burden
Selective clearance of senescent cells that sustain chronic inflammation in aged tissue.
Chronic inflammation
Signalling by cytokines associated with age-dependent fibrosis and inflammation.
Extracellular matrix
Stiffness of the tissue niche and its effect on regenerative capacity.
Cofactor metabolism
Availability of the substrate consumed by the enzymes of epigenetic maintenance.
Measurement
No validated functional endpoint exists for rejuvenation interventions in humans. It is the problem that constrains the evaluation of every other one.
What being in Phase 1 means
There is no laboratory, no trials under way and no results of our own. The work of this phase is documentary and methodological, and it produces criteria rather than molecules.
- 01
Read the actual frontier
What has been demonstrated, in which species, with what endpoint and at what effect size. The review is done against the primary source, not against popular accounts.
- 02
Document the limitations
Every line of work in the field has a limit described in its own literature. It is recorded alongside the evidence, not separately.
- 03
Set evaluation criteria
Which result would make us abandon a hypothesis, decided and written down before anything is run.
- 04
Publish the method
The articles on this site are the visible output of the phase. Every figure states where it comes from and in which model it was obtained.
Articles
We write about the state of the field and about the method we use to review it. No calendar: articles are published once reference verification is complete.
Working with us
There are no open hiring processes. There is interest in talking to researchers, laboratories and contract research organisations.
- 01Research. Cellular senescence, extracellular matrix, NAD⁺ metabolism and partial reprogramming.
- 02Laboratories and CROs. Execution and quotation of experimental designs in human cell models.
- 03Measurement methodology. Development or validation of functional endpoints.
- 04Corrections. Citation errors or prior work not covered in what we publish.